Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases

Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration.

The kynurenine aminotransferases (KATs) KAT I and KAT II are pivotal to the synthesis of kynurenic acid (KYNA), the only known endogenous glutamate receptor antagonist and neuroprotectant. KAT I and II have been found in avian, rodent, and human retina. Expression of KAT I in Müller cell endfeet and KAT II in retinal ganglion cells has been documented. Developmental changes in KAT expression an...

Thermal and pH stability of feline calicivirus.

Molar concentration of sodium chloride partially stabilized feline calicivirus against thermal inactivation at 50 C. One strain of feline calicivirus was relatively acid labile compared to another.

Thermal and pH stability of pestiviruses.

Three strains/isolates of hog cholera virus (HCV) and two strains/isolates each of cytopathogenic (cp) and non-cytopathogenic (ncp) biotype of bovine virus diarrhoea virus (BVDV) were each exposed to pH 3, 3.5 and 4 at 4 degrees C, 21 degrees C and 37 degrees C in a number of combinations. Infectivity titration and half-life determinations following correlation and regression analysis showed a ...

Expression of kynurenine aminotransferases in the rat retina during development

The study investigates the cellular expression of kynurenine aminotransferases (KAT I and II) in the rat retina during development. At P1 (the day of birth) and P7 (the 7th day after birth), KAT I expression was observed in the inner plexiform layer (IPL), the fiber layer (FL), and in vertically running processes in the ganglion cell layer (GCL) (but not in the cell bodies). At P14 (the 14th da...

pH dependence of the inhibition of yeast glyoxalase 1 by prophyrins